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Preclinical Pharmacology and Toxicology
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Epilepsy
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Maximal electroshock-induced seizure in mouse or rat
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Chemically induced seizure in mouse or rat
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We have screened many dozens of compounds with MES in mouse. This simple test allows high throughput, and toxicology measures such as rotorod performance and temperature can be generated simultaneously.
James L. Howard was the international project leader for the development of an anticonvulsant through Phase I clinical trials.
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