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Preclinical Pharmacology and Toxicology
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Pain and Inflammation
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- Hot plate in mouse or rat
- Formalin-induced paw licking in mouse
- Carrageenan-induced hyperalgesia in rat
- Phenylquinone- or acetic acid-induced writhing in mouse
- Mustard oil-induced visceral pain in mouse (TRP A1)
- Carrageenan-induced pleurisy in rat
- Adjuvant-induced arthritis in rat
- Other tests that can be set up: Chung model of neuropathic pain
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As with MES, the simple mouse models allow high throughput and economies of scale.
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Publications
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Chang, K.J., Rigdon, G.C., Howard, J.L., & McNutt, R.W. (1993). A potent and selective non-peptide delta-receptor agonist. Journal of Pharmacology and Experimental Therapeutics, 267, 852-857.
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